CpG/DNA methylation

Posted on Fri 09 March 2018 in Fundamentals

CpG methylation

CpG methylation is an epigenetic modification on DNA. At the molecular level, CpG methylation involves the addition of a methyl (CH3) group on the C5 atom of cytosine, yeilding 5-methylcytosine (5mC). Although the change is very small, but cumulative effect is profound, for example X-chromosome inactivation. Recent work have suggested impact of methylation on protein My research work has revealed insights into the methyl-induced structural deformations and its applications protein-DNA interactions.

My little contribution

In my PhD work, I attempted to explain the effect of CpG methylation on shape-readout, one of the binding recognition mode, utilized by Transription Factors (TFs). The details can be found here.